Spravato® Treatment in Denver
(Highland / LoHi | 80211)
FDA-Approved Esketamine Therapy for Treatment-Resistant Depression
Stellar Genesis PLLC offers FDA-approved Spravato® (esketamine) treatment in Denver’s Highland and LoHi neighborhood. If you’re searching for Spravato near me, Spravato Denver, or Spravato treatment center 80211, our clinic provides compassionate, medically supervised care for people struggling with depression that hasn’t responded to traditional treatments.
We are a REMS-certified Spravato treatment center, meaning we meet all federal safety requirements for in-clinic administration and monitoring.
What Is Spravato (Esketamine)?
Spravato is a prescription nasal spray form of esketamine, approved by the FDA for adults with:
Treatment-resistant depression (TRD)
Major depression with acute suicidal thoughts
Unlike standard antidepressants that work on serotonin or norepinephrine, Spravato targets NMDA receptors in the brain’s glutamate system, helping restore neural connections involved in mood, cognition, and emotional regulation.
Many patients experience faster symptom relief, sometimes within days rather than weeks.
Spravato is not a take-home medication and must be administered in a certified medical clinic under supervision.
Am I a Good Candidate
for Spravato®?
Spravato may be appropriate if you
Have tried two or more antidepressants without adequate improvement
Continue to struggle with depression despite therapy or medication
Are seeking an insurance-covered alternative to IV ketamine
Need a treatment option with faster onset of relief
Our providers perform a careful evaluation to ensure Spravato is safe and appropriate for you.
How does SPRAVATO® Work?
SPRAVATO® targets the N-methyl-D-aspartate (NMDA) receptor and is believed to work differently than currently available oral antidepressants. The exact way that SPRAVATO® works is unknown.
How often will I receive treatment?
Adults with Treatment-Resistant Depression (TRD)
WEEKS 1-4
Twice weekly
WEEKS 5-8
Once weekly
MAINTENANCE
Once per week or
Individual basis
Depending on which treatment you receive, you and your healthcare provider will determine if continued treatment with SPRAVATO® is necessary.
What Happens Next
Schedule consult
Insurance check
First visit (vitals, intake)
Start treatment
Is Spravato Safe?
What Are the Side Effects?
Spravato is safe when administered in a REMS-certified clinic.
Common short-term effects may include:
Dissociation or feeling “spacey”
Dizziness or nausea
Temporary blood pressure increase
Fatigue or sedation
These effects usually resolve before you leave the clinic.
Sexual side effects are rare compared to traditional antidepressants.
Spravato Cost &
Insurance Coverage in Colorado
Spravato is covered by most insurance plans, including:
Blue Cross Blue Shield
Aetna
Colorado Medicaid
Our office handles insurance verification and prior authorization.
Manufacturer assistance programs may reduce out-of-pocket costs for eligible patients.
Common searches we help with:
Is Spravato covered by insurance?Spravato cost with insurance
Why Choose Stellar Genesis PLLC for Spravato in Denver?
-
REMS-certified Spravato treatment center
Compassionate, trauma-informed care
Private, calming treatment rooms
Set & Setting
Convenient Highland / LoHi location (80211)
Coordination with therapists and referring providers
We believe depression care should feel human, respectful, and safe.
What to Expect During your
SPRAVATO® Treatment
You will not be able to drive, so you will need to plan transportation for treatment days.
You will administer the nasal spray yourself under the supervision of a healthcare provider.
You'll be monitored for side effects for at least two hours.
Your healthcare provider will tell you when it's OK to leave.
Do not drive, operate machinery or do anything where you need to be completely alert until the day after a treatment session, following a restful sleep.
SPRAVATO® Testimonial:
Ben’s Story
Meet Ben, a 40-year-old from New York who has treatment-resistant depression (TRD). His internal struggles led to feelings of worthlessness and isolation, affecting his daily life.
Ben had tried multiple antidepressants before his psychiatrist recommended SPRAVATO®. Learn more about Ben’s SPRAVATO® (esketamine) treatment experience and his experience with treatment-resistant depression in this video.
You are not alone. Millions of Americans suffer from
treatment-resistant depression.
Major depressive disorder (MDD), also known as clinical depression, is one of the most common mental health disorders in the United States, affecting more than 21 million adults.
Clinical depression symptoms may include depressed mood, loss of interest in daily activities, change in sleep, appetite or weight, fatigue, diminished concentration or slowed thoughts, feelings of worthlessness and/or suicidal ideation.
According to a study, 1 in 3 people did not experience a reduction in their depressive symptoms when taking antidepressants alone.
When two or more antidepressants don’t provide relief for clinical depression, this is commonly known as treatment-resistant depression.
Frequently Asked Questions
1. How long does Spravato take to work?
Many patients begin to notice improvement within the first few treatments, sometimes within 1–2 weeks. For others, it may take a few weeks of consistent sessions. Spravato is typically given twice weekly at the beginning, then spaced out over time based on your response.
2. How much does Spravato cost in Denver?
The cost of Spravato can vary depending on your insurance coverage. Many insurance plans, including Aetna, BCBS, and others, may cover a significant portion of the treatment when medically indicated. Our clinic will help verify your benefits and guide you through the process so you understand your out-of-pocket costs.
3. Is Spravato covered by insurance?
Yes, Spravato is FDA-approved and often covered by insurance for treatment-resistant depression or major depression with suicidal thoughts. Coverage depends on your individual plan. We assist with prior authorization and work closely with your insurance to make the process as smooth as possible.
4. Do I need someone to drive me home after treatment?
Yes. Because Spravato can cause temporary sedation, dizziness, or dissociation, you are required to have a safe ride home after each session. You should not drive or operate machinery until the next day after a restful sleep.
5. What happens during a Spravato session?
Spravato is administered as a nasal spray in a comfortable, monitored clinical setting. After dosing, you will relax in a calm environment for about 2 hours while we monitor your blood pressure and overall response. Many patients use this time for quiet reflection, music, or rest.
6. What are the side effects of Spravato?
Common side effects include dizziness, nausea, increased blood pressure, sedation, and dissociation (a feeling of being disconnected). These effects are usually temporary and monitored closely during your visit. We prioritize safety and support throughout your treatment.
7. Who is a good candidate for Spravato?
Spravato is typically recommended for individuals who:
Have tried at least two antidepressants without sufficient improvement
Are experiencing treatment-resistant depression
May be struggling with persistent depressive symptoms or suicidal thoughts
A full medical and psychiatric evaluation is required to determine if this treatment is appropriate for you.
8. How is Spravato different from ketamine therapy?
Spravato (esketamine) is FDA-approved and administered under a REMS-certified program in a clinical setting with monitoring. Ketamine therapy may be used off-label and can vary in how it is delivered. Both can be effective, and we help determine the best approach based on your needs.
9. How often do I need to come in for treatment?
Treatment typically starts with twice-weekly visits for the first 4 weeks, followed by weekly or every-other-week sessions depending on your progress and response.
10. What is the next step if I’m interested in Spravato?
The first step is to schedule a consultation. We will review your history, check your insurance coverage, and create a personalized treatment plan. We also collaborate with your therapist or referring provider when appropriate.
Schedule a Spravato Consultation in Denver
If you’re searching for Spravato treatment center Highland / LoHi,
Spravato Treatment in Denver (Esketamine Therapy Near You)
we’re here to help.
📍 Stellar Genesis PLLC – Denver Highland / LoHi (80211)
📞 Contact us to schedule a consultation
🗓 Insurance verification available