Spravato® Treatment in Denver
(Highland / LoHi | 80211)
FDA-Approved Esketamine Therapy for Treatment-Resistant Depression
Stellar Genesis PLLC offers FDA-approved Spravato® (esketamine) treatment in Denver’s Highland and LoHi neighborhood. If you’re searching for Spravato near me, Spravato Denver, or Spravato treatment center 80211, our clinic provides compassionate, medically supervised care for people struggling with depression that hasn’t responded to traditional treatments.
We are a REMS-certified Spravato treatment center, meaning we meet all federal safety requirements for in-clinic administration and monitoring.
What Is Spravato (Esketamine)?
Spravato is a prescription nasal spray form of esketamine, approved by the FDA for adults with:
Treatment-resistant depression (TRD)
Major depression with acute suicidal thoughts
Unlike standard antidepressants that work on serotonin or norepinephrine, Spravato targets NMDA receptors in the brain’s glutamate system, helping restore neural connections involved in mood, cognition, and emotional regulation.
Many patients experience faster symptom relief, sometimes within days rather than weeks.
Spravato is not a take-home medication and must be administered in a certified medical clinic under supervision.
Who Is a Good Candidate for Spravato®?
Spravato may be appropriate if you:
Have tried two or more antidepressants without adequate improvement
Continue to struggle with depression despite therapy or medication
Are seeking an insurance-covered alternative to IV ketamine
Need a treatment option with faster onset of relief
Our providers perform a careful evaluation to ensure Spravato is safe and appropriate for you.
How does SPRAVATO® Work?
SPRAVATO® targets the N-methyl-D-aspartate (NMDA) receptor and is believed to work differently than currently available oral antidepressants. The exact way that SPRAVATO® works is unknown.
How often will I receive treatment?
Adults with Treatment-Resistant Depression (TRD)
WEEKS 1-4
Twice weekly
WEEKS 5-8
Once weekly
MAINTENANCE
Once per week or
Individual basis
Depending on which treatment you receive, you and your healthcare provider will determine if continued treatment with SPRAVATO® is necessary.
Is Spravato Safe? What Are the Side Effects?
Spravato is considered safe when administered in a REMS-certified clinic.
Common short-term effects may include:
Dissociation or feeling “spacey”
Dizziness or nausea
Temporary blood pressure increase
Fatigue or sedation
These effects usually resolve before you leave the clinic.
Sexual side effects are rare compared to traditional antidepressants.
Spravato Cost & Insurance Coverage in Colorado
Spravato is covered by most insurance plans, including:
Blue Cross Blue Shield
Aetna
Colorado Medicaid
Our office handles insurance verification and prior authorization.
Manufacturer assistance programs may reduce out-of-pocket costs for eligible patients.
Common searches we help with:
Is Spravato covered by insurance? Spravato cost with insurance
Why Choose Stellar Genesis PLLC for Spravato in Denver?
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REMS-certified Spravato treatment center
Compassionate, trauma-informed care
Private, calming treatment rooms
Set & Setting
Convenient Highland / LoHi location (80211)
Coordination with therapists and referring providers
We believe depression care should feel human, respectful, and safe.
What to Expect During your
SPRAVATO® Treatment
You will not be able to drive, so you will need to plan transportation for treatment days.
You will administer the nasal spray yourself under the supervision of a healthcare provider.
You'll be monitored for side effects for at least two hours.
Your healthcare provider will tell you when it's OK to leave.
Do not drive, operate machinery or do anything where you need to be completely alert until the day after a treatment session, following a restful sleep.
SPRAVATO® Testimonial:
Ben’s Story
Meet Ben, a 40-year-old from New York who has treatment-resistant depression (TRD). His internal struggles led to feelings of worthlessness and isolation, affecting his daily life.
Ben had tried multiple antidepressants before his psychiatrist recommended SPRAVATO®. Learn more about Ben’s SPRAVATO® (esketamine) treatment experience and his experience with treatment-resistant depression in this video.
You are not alone. Millions of Americans suffer from
treatment-resistant depression.
Major depressive disorder (MDD), also known as clinical depression, is one of the most common mental health disorders in the United States, affecting more than 21 million adults.
Clinical depression symptoms may include depressed mood, loss of interest in daily activities, change in sleep, appetite or weight, fatigue, diminished concentration or slowed thoughts, feelings of worthlessness and/or suicidal ideation.
According to a study, 1 in 3 people did not experience a reduction in their depressive symptoms when taking antidepressants alone.
When two or more antidepressants don’t provide relief for clinical depression, this is commonly known as treatment-resistant depression.
Frequently Asked Questions
Spravato is a form of ketamine (esketamine) but is FDA-approved, regulated, and usually covered by insurance.
How quickly does Spravato work?
Some patients notice improvement within days; others improve over several weeks.
Do I need a referral?
No referral is required. We can also coordinate with your psychiatrist or therapist.
Schedule a Spravato Consultation in Denver
If you’re searching for Spravato Denver, Spravato near me, or Spravato treatment center Highland / LoHi,
we’re here to help.
📍 Stellar Genesis PLLC – Denver Highland / LoHi (80211)
📞 Contact us to schedule a consultation
🗓 Insurance verification available