What Is SPRAVATO®?
SPRAVATO® is the only FDA-approved nasal spray for adults with treatment-resistant depression that can be taken with or without an oral antidepressant.
SPRAVATO® can help reduce depression symptoms when antidepressants haven’t worked well for you.
How does SPRAVATO® Work?
SPRAVATO® targets the N-methyl-D-aspartate (NMDA) receptor and is believed to work differently than currently available oral antidepressants. The exact way that SPRAVATO® works is unknown.
How often will I receive treatment?
Adults with Treatment-Resistant Depression (TRD)
WEEKS 1-4
Twice weekly
WEEKS 5-8
Once weekly
MAINTENANCE
Once per week or
Individual basis
Depending on which treatment you receive, you and your healthcare provider will determine if continued treatment with SPRAVATO® is necessary.
What to Expect During your
SPRAVATO® Treatment
You will not be able to drive, so you will need to plan transportation for treatment days.
You will administer the nasal spray yourself under the supervision of a healthcare provider.
You'll be monitored for side effects for at least two hours.
Your healthcare provider will tell you when it's OK to leave.
Do not drive, operate machinery or do anything where you need to be completely alert until the day after a treatment session, following a restful sleep.
SPRAVATO® Testimonial:
Ben’s Story
Meet Ben, a 40-year-old from New York who has treatment-resistant depression (TRD). His internal struggles led to feelings of worthlessness and isolation, affecting his daily life.
Ben had tried multiple antidepressants before his psychiatrist recommended SPRAVATO®. Learn more about Ben’s SPRAVATO® (esketamine) treatment experience and his experience with treatment-resistant depression in this video.
You are not alone. Millions of Americans suffer from
treatment-resistant depression.
Major depressive disorder (MDD), also known as clinical depression, is one of the most common mental health disorders in the United States, affecting more than 21 million adults.
Clinical depression symptoms may include depressed mood, loss of interest in daily activities, change in sleep, appetite or weight, fatigue, diminished concentration or slowed thoughts, feelings of worthlessness and/or suicidal ideation.
According to a study, 1 in 3 people did not experience a reduction in their depressive symptoms when taking antidepressants alone.
When two or more antidepressants don’t provide relief for clinical depression, this is commonly known as treatment-resistant depression.